Perfect Game
| Name | Opponent | Date |
|---|
| Cy Young | Philadelphia Athletics | 5/5/1904 |
No-Hitter
| Name | Opponent | Date |
|---|
| Jon Lester | Kansas City Royals | 5/19/2008 |
| Clay Buchholz | Baltimore Orioles | 9/1/2007 |
| Derek Lowe | Tampa Bay Devil Rays | 4/27/2002 |
| Hideo Nomo | Baltimore Orioles | 4/4/2001 |
| Dave Morehead | Cleveland Indians | 9/16/1965 |
| Bill Monbouquette | Chicago White Sox | 8/1/1962 |
| Earl Wilson | Los Angeles Angels | 6/26/1962 |
| Mel Parnell | Chicago White Sox | 7/14/1956 |
| Howard Ehmke | Philadelphia Athletics | 9/7/1923 |
| Dutch Leonard | Detroit Tigers | 6/3/1918 |
| Babe Ruth, Ernie Shore | Washington Senators | 6/23/1917 |
| Dutch Leonard | St. Louis Browns | 8/30/1916 |
| Rube Foster | New York Yankees | 6/21/1916 |
| Joe Wood | St. Louis Browns | 7/29/1911 |
| Cy Young | New York Highlanders | 6/30/1908 |
| Bill Dinneen | Chicago White Sox | 9/27/1905 |
| Jesse Tannehill | Chicago White Sox | 8/17/1904 |
Hitting for the Cycle
| Name | Opponent | Date |
|---|
| Brock Holt | New York Yankees | 10/8/2018
ALDS Game 3 |
| Mookie Betts | Toronto Blue Jays | 8/9/2018 |
| Brock Holt | Atlanta Braves | 6/16/2015 |
| John Valentin | Chicago White Sox | 6/6/1996 |
| Scott Cooper | Kansas City Royals | 4/12/1994 |
| Mike Greenwell | Baltimore Orioles | 9/14/1988 |
| Rich Gedman | Toronto Blue Jays | 9/18/1985 |
| Dwight Evans | Seattle Mariners | 6/28/1984 |
| Fred Lynn | Minnesota Twins | 5/13/1980 |
| Bob Watson | Baltimore Orioles | 9/15/1979 |
| Carl Yastrzemski | Detroit Tigers | 5/14/1965 |
| Lou Clinton | Kansas City Athletics | 7/13/1962 |
| Bobby Doerr | Chicago White Sox | 5/13/1947 |
| Ted Williams | St. Louis Browns | 7/21/1946 |
| Bob Johnson | Detroit Tigers | 7/6/1944 |
| Bobby Doerr | St. Louis Browns | 5/17/1944 |
| Leon Culberson | Cleveland Indians | 7/3/1943 |
| Joe Cronin | Detroit Tigers | 8/2/1940 |
| Moose Solters | Detroit Tigers | 8/19/1934 |
| Roy Carlyle | Chicago White Sox | 7/21/1925 |
| Tris Speaker | St. Louis Browns | 6/9/1912 |
| Patsy Dougherty | New York Highlanders | 7/29/1903 |
| Buck Freeman | Cleveland Naps | 6/21/1903 |
