Rays Roster & Staff
Transactions
| Date | Transaction |
| 04/29/22 | Tampa Bay Rays optioned LHP Ben Bowden to Durham Bulls. |
| 04/29/22 | Tampa Bay Rays claimed LHP Ben Bowden off waivers from Colorado Rockies. |
| 04/25/22 | Tampa Bay Rays optioned 2B Vidal Brujan to Durham Bulls. |
| 04/24/22 | Tampa Bay Rays activated 3B Yandy Díaz from the 10-day injured list. |
| 04/24/22 | Tampa Bay Rays placed LHP Jeffrey Springs on the 10-day injured list. |
| 04/23/22 | Tampa Bay Rays sent LHP Ryan Yarbrough on a rehab assignment to Durham Bulls. |
| 04/23/22 | Tampa Bay Rays placed 3B Yandy Diaz on the 10-day injured list. |
| 04/23/22 | Tampa Bay Rays recalled 2B Vidal Brujan from Durham Bulls. |
| 04/22/22 | Tampa Bay Rays placed RHP Chris Mazza on the 10-day injured list. Lower back spasm. |
| 04/22/22 | Tampa Bay Rays placed RHP Chris Mazza on the 10-day injured list retroactive to April 18, 2022. Low back spasm. |
| 04/22/22 | Tampa Bay Rays placed C Francisco Mejia on the 10-day injured list. |
| 04/22/22 | Tampa Bay Rays recalled LHP Colin Poche from Durham Bulls. |
| 04/22/22 | Tampa Bay Rays recalled C Rene Pinto from Durham Bulls. |
| 04/20/22 | Tampa Bay Rays signed free agent RHP Landany Alfonseca to a minor league contract. |
| 04/18/22 | Tampa Bay Rays activated RHP Javy Guerra. |
| 04/18/22 | Tampa Bay Rays optioned RHP Tommy Romero to Durham Bulls. |
| 04/17/22 | Tampa Bay Rays sent RHP Dusten Knight outright to Durham Bulls. |
| 04/16/22 | Tampa Bay Rays reassigned RHP Javy Guerra to the minor leagues. |
| 04/16/22 | Tampa Bay Rays transferred RHP Shane Baz from the 10-day injured list to the 60-day injured list. Right elbow surgery. |
| 04/16/22 | Tampa Bay Rays reassigned RHP Javy Guerra to the minor leagues. |
| 04/16/22 | San Diego Padres traded RHP Javy Guerra to Tampa Bay Rays for cash. |
| 04/14/22 | Tampa Bay Rays designated RHP Dusten Knight for assignment. |
| 04/14/22 | Tampa Bay Rays selected the contract of RHP Phoenix Sanders, and from Durham Bulls. |
| 04/13/22 | Tampa Bay Rays transferred RHP Luis Patino from the 10-day injured list to the 60-day injured list. |
| 04/13/22 | Tampa Bay Rays optioned RHP Ralph Garza Jr. to Durham Bulls. |
| 04/13/22 | Tampa Bay Rays selected the contract of RHP Dusten Knight from Durham Bulls. |
| 04/12/22 | Tampa Bay Rays placed RHP Luis Patino on the 10-day injured list. Left oblique strain. |
| 04/12/22 | Tampa Bay Rays placed RHP JT Chargois on the 10-day injured list retroactive to April 9, 2022. Left oblique tightness. |
| 04/12/22 | Tampa Bay Rays recalled RHP Tommy Romero, and from Durham Bulls. |
| 04/12/22 | Tampa Bay Rays recalled RHP Ralph Garza Jr. from Durham Bulls. |
| 04/11/22 | Tampa Bay Rays placed LHP Ryan Yarbrough on the 10-day injured list retroactive to April 8, 2022. Left groin tightness. |
| 04/11/22 | Tampa Bay Rays recalled RHP Ryan Thompson, and from Durham Bulls. |
| 04/07/22 | Tampa Bay Rays transferred LHP Brendan McKay from the 7-day injured list to the 60-day injured list. Thoracic outlet syndrome decompression surgery. |
| 04/07/22 | Tampa Bay Rays activated RHP Chris Mazza. |
| 04/07/22 | Tampa Bay Rays placed RHP Pete Fairbanks on the 60-day injured list. Right lat strain. |
| 04/07/22 | Tampa Bay Rays activated RHP Chris Mazza. |
| 04/07/22 | Tampa Bay Rays selected the contract of RHP Chris Mazza from Durham Bulls. |
| 04/07/22 | Tampa Bay Rays optioned RHP Ralph Garza Jr. to Durham Bulls. |
| 04/07/22 | Tampa Bay Rays claimed RHP Ralph Garza Jr. off waivers from Boston Red Sox. |
| 04/07/22 | Tampa Bay Rays recalled LHP Brendan McKay from Durham Bulls. |
| 04/06/22 | Tampa Bay Rays signed free agent LHP Chariel Radney to a minor league contract. |
| 04/06/22 | OF Stir Candelario and assigned to Tampa Bay Rays. |
| 04/06/22 | Tampa Bay Rays optioned LF Luke Raley to Durham Bulls. |
| 04/05/22 | RF Oneill Manzueta and assigned to Tampa Bay Rays. |
| 04/05/22 | C Felix Salguera and assigned to Tampa Bay Rays. |
| 04/05/22 | LHP Maicor Leon and assigned to Tampa Bay Rays. |
| 04/05/22 | Tampa Bay Rays optioned LHP Colin Poche to Durham Bulls. |
| 04/05/22 | Tampa Bay Rays optioned SS Isaac Paredes to Durham Bulls. |
| 04/05/22 | Tampa Bay Rays optioned RHP Ryan Thompson to Durham Bulls. |
| 04/05/22 | Detroit Tigers traded SS Isaac Paredes to Tampa Bay Rays for LF Austin Meadows. |
| 04/05/22 | Detroit Tigers traded SS Isaac Paredes to Tampa Bay Rays for LF Austin Meadows. |
| 04/05/22 | Tampa Bay Rays recalled 3B Josh Lowe, and from Durham Bulls. |
| 04/04/22 | C Christian Cerda and assigned to Tampa Bay Rays. |
| 04/04/22 | OF Estanli Castillo and assigned to Tampa Bay Rays. |
| 04/04/22 | Tampa Bay Rays signed free agent C Nathan Perry to a minor league contract. |
| 04/04/22 | 1B Freddvil Chevez and assigned to Tampa Bay Rays. |
| 04/04/22 | SS Carlos Colmenarez and assigned to Tampa Bay Rays. |
| 04/04/22 | RHP Anthony Molina and assigned to Tampa Bay Rays. |
| 04/04/22 | OF Patrick Merino and assigned to Tampa Bay Rays. |
| 04/04/22 | CF Christian Johnson and assigned to Tampa Bay Rays. |
| 04/04/22 | SS Alejandro Pie and assigned to Tampa Bay Rays. |
| 04/04/22 | RHP Matthew Peguero and assigned to Tampa Bay Rays. |
| 04/04/22 | OF Daiwer Castellanos and assigned to Tampa Bay Rays. |
| 04/04/22 | Tampa Bay Rays placed RHP Shane Baz on the 10-day injured list. Right elbow surgery. |
| 04/04/22 | Tampa Bay Rays traded RHP David McKay to New York Yankees for cash. |
| 04/03/22 | RHP Nomar Rojas and assigned to Tampa Bay Rays. |
| 04/03/22 | OF Mason Auer and assigned to Tampa Bay Rays. |
| 04/03/22 | SS Abiezel Ramirez and assigned to Tampa Bay Rays. |
| 04/03/22 | SS Alika Williams and assigned to Tampa Bay Rays. |
| 04/03/22 | OF Dru Baker and assigned to Tampa Bay Rays. |
| 04/01/22 | SS Tanner Murray and assigned to Tampa Bay Rays. |
| 04/01/22 | RHP Addison Moss and assigned to Tampa Bay Rays. |
| 04/01/22 | CF Shane Sasaki and assigned to Tampa Bay Rays. |
| 04/01/22 | Tampa Bay Rays released 2B Connor Hollis. |