MIAMI -- When Joe Panik sent the first pitch of Tuesday's game over the right-field wall at Marlins Park, it appeared as though the Giants might have successfully regrouped 3,111 miles from home after a 1-6 homestand and off-day in South Florida.

Things quickly unraveled in San Francisco's 11-3 loss to the Marlins for a season-high sixth consecutive defeat to open a nine-game, three-city road trip.

Right-hander Jeff Samardzija allowed five runs on eight hits over four-plus innings. Righty Nick Vincent took over with two men on base in the fifth and surrendered Jorge Alfaro's three-run shot before exiting in the sixth with a right pectoral strain. Southpaw Derek Holland, an option to start Thursday's finale, gave up a three-run shot of his own as the Marlins scored 11 consecutive runs.

"You can't get off to a better start," Giants manager Bruce Bochy said. "Leadoff hitter hits the first pitch out of the ballpark and you think the momentum was going to swing over. 'We'll get these bats going,' and it was just the opposite."

• Box score

Burned ahead in the count

Entering Tuesday, the Giants had surrendered 120 two-out runs -- most in the National League and third overall. With two strikes, the pitching staff had allowed 111 runs -- also tops in the NL and second in the Majors.

That trend continued as the Marlins' first seven runs came with two outs, including all three of their homers. Each long ball was on a two-strike pitch.

For a rotation with a 7.15 ERA through the first 22 games of May, the second-highest mark in the Majors, the Giants can ill afford to give the opposition hittable pitches when ahead in the count.

"Pitching with runners in scoring position is huge. That's where you make your money or get hurt. If you can get outs with guys on the bags, you're having a good day, you're having a good run," said Samardzija, who finished May with a 5.55 ERA and 1.48 WHIP. "That's what big league pitchers do.

"Obviously, those two stats aren't ideal, it's not what you want. It's something that needs to be addressed with us. You're ahead in the count, you don't want to take any damage. You want to put guys away. We're an aggressive pitching staff, and obviously we don't like walks, but there's a fine line you have to walk to not be giving up silly hits and silly runs."

Alfaro tattooed Vincent's 1-2 four-seam fastball into the right-center seats. Garrett Cooper knocked Holland's 0-2 knuckle curveball into the new standing room section in center field and Rosell Herrera sent righty Sam Coonrod's 1-2 four-seam fastball into the second deck in the eighth.

According to Bochy, the issue isn't pitch selection.

"That's just poor concentration and execution," Bochy said. "There's no excuses for that. ... You look where these balls are, those balls can't be there in that situation. Different areas to go, we just made mistakes and they took advantage of it."

Scuffling bats

After Panik's third homer of the season, San Francisco didn't record another hit until Brandon Crawford's infield single in the fifth. Marlins right-hander Trevor Richards retired 21 of his final 23 batters after Panik's leadoff blast.

San Francisco registered just two balls put in play with an exit velocity over 100 mph.

"We're not making good, hard contact," Bochy said. "The bats are not there. You look at the last four games, and that's been part of it. ... Where we're at in the order, we definitely have to get some guys going with the bats. There were some easy outs there. Wasn't a lot of hard contact. That's kind of been our issue these last four games."

Veteran Evan Longoria, who went hitless in four at-bats, said the message around the clubhouse needs to revolve around showing up with the same mindset on a daily basis and forgetting about the previous game.

A two-run ninth, which saw Crawford try to beat the shift with a two-out bunt down 11-2, was aided by a pair of infield singles. The Giants have been outscored, 45-11, over their past four games.

"It's hard to have fun when you're losing. Usually when you're winning, you're having fun," Longoria said. "You have to find a way to do both and at least start with putting some good innings together and playing some competitive games. These last four games we've played have been maybe competitive for a couple innings and we're out of it.

"From an offensive standpoint, we just have to continue to go inning by inning and find ways to put pressure and put runners out there and find ways. When we stay out on the field for a good while, [we have to] to come in and have an extended inning ourselves instead of just going up there and going 1-2-3 and going back out on defense. Whatever the plan has to be, whatever the adjustments we have to make, we have to try and do that."