Giants Roster & Staff
Transactions
| Date | Transaction |
| 04/30/22 | San Francisco Giants optioned LF Ka'ai Tom to Sacramento River Cats. |
| 04/30/22 | Miami Marlins traded SS Isan Diaz to San Francisco Giants for cash. |
| 04/29/22 | San Francisco Giants placed 1B Brandon Belt on the 10-day injured list. |
| 04/29/22 | San Francisco Giants placed RHP Dominic Leone on the 10-day injured list. |
| 04/29/22 | San Francisco Giants released LHP Darien Nunez. |
| 04/29/22 | San Francisco Giants selected the contract of LF Ka'ai Tom from Sacramento River Cats. |
| 04/29/22 | San Francisco Giants selected the contract of RHP Mauricio Llovera from Sacramento River Cats. |
| 04/29/22 | San Francisco Giants selected the contract of LF Jason Krizan from Sacramento River Cats. |
| 04/28/22 | San Francisco Giants optioned RHP Jakob Junis to Sacramento River Cats. |
| 04/28/22 | Boston Red Sox claimed RF Jaylin Davis off waivers from San Francisco Giants. |
| 04/27/22 | San Francisco Giants optioned 3B Kevin Padlo to Sacramento River Cats. |
| 04/27/22 | San Francisco Giants claimed LHP Darien Nunez off waivers from Los Angeles Dodgers. |
| 04/26/22 | San Francisco Giants placed RHP Zack Littell on the 10-day injured list. |
| 04/26/22 | Seattle Mariners traded 3B Kevin Padlo to San Francisco Giants for cash. |
| 04/26/22 | San Francisco Giants recalled RHP Kervin Castro from Sacramento River Cats. |
| 04/25/22 | San Francisco Giants placed RF Mike Yastrzemski on the 10-day injured list. |
| 04/25/22 | San Francisco Giants recalled 3B Luke Williams from Sacramento River Cats. |
| 04/22/22 | San Francisco Giants placed RHP Anthony DeSclafani on the 10-day injured list. Right ankle inflammation. |
| 04/22/22 | San Francisco Giants placed CF Steven Duggar on the 60-day injured list. Left oblique strain. |
| 04/22/22 | San Francisco Giants recalled RHP Jakob Junis from Sacramento River Cats. |
| 04/22/22 | San Francisco Giants selected the contract of OF Luis Gonzalez from Sacramento River Cats. |
| 04/21/22 | San Francisco Giants designated RF Jaylin Davis for assignment. |
| 04/21/22 | Chicago Cubs traded RHP Cory Abbott to San Francisco Giants. |
| 04/20/22 | San Francisco Giants optioned 3B Luke Williams to Sacramento River Cats. |
| 04/19/22 | San Francisco Giants placed RHP Alex Cobb on the 10-day injured list. Right adductor strain. |
| 04/19/22 | San Francisco Giants recalled 3B Jason Vosler from Sacramento River Cats. |
| 04/19/22 | San Francisco Giants recalled 3B Luke Williams from Sacramento River Cats. |
| 04/19/22 | San Francisco Giants optioned 3B Luke Williams to Sacramento River Cats. |
| 04/19/22 | San Francisco Giants recalled RHP Yunior Marte from Sacramento River Cats. |
| 04/16/22 | San Francisco Giants signed free agent LHP Daniel Tillo to a minor league contract. |
| 04/15/22 | San Francisco Giants activated RHP Tyler Rogers from the paternity list. |
| 04/15/22 | San Francisco Giants activated RHP Tyler Rogers from the paternity list. |
| 04/15/22 | San Francisco Giants activated RHP Tyler Rogers from the paternity list. |
| 04/14/22 | San Francisco Giants optioned OF Heliot Ramos to Sacramento River Cats. |
| 04/13/22 | San Francisco Giants activated RHP John Brebbia from the bereavement list. |
| 04/13/22 | San Francisco Giants optioned RHP Yunior Marte to Sacramento River Cats. |
| 04/12/22 | San Francisco Giants placed RHP Tyler Rogers on the paternity list. |
| 04/12/22 | San Francisco Giants recalled RHP Yunior Marte from Sacramento River Cats. |
| 04/10/22 | San Francisco Giants placed RHP John Brebbia on the bereavement list. |
| 04/10/22 | San Francisco Giants recalled OF Heliot Ramos from Sacramento River Cats. |
| 04/07/22 | San Francisco Giants optioned 3B Jason Vosler to Sacramento River Cats. |
| 04/04/22 | C Rodolfo Bone assigned to San Francisco Giants. |
| 04/04/22 | San Francisco Giants placed 2B Tommy La Stella on the 10-day injured list. Right Achilles inflammation. |
| 04/04/22 | San Francisco Giants placed 3B Evan Longoria on the 10-day injured list. Recovery from right hand surgery. |
| 04/04/22 | San Francisco Giants placed CF LaMonte Wade Jr. on the 10-day injured list. Left knee inflammation. |
| 04/04/22 | C Rodolfo Bone roster status changed by San Francisco Giants. |
| 04/03/22 | San Francisco Giants optioned RHP Kervin Castro to Sacramento River Cats. |
| 04/03/22 | San Francisco Giants optioned RHP Jakob Junis to Sacramento River Cats. |
| 04/01/22 | LHP Juan Sanchez and assigned to San Francisco Giants. |