Cardinals Roster & Staff
Transactions
| Date | Transaction |
| 09/21/22 | St. Louis Cardinals optioned LHP Packy Naughton to Memphis Redbirds. |
| 09/21/22 | St. Louis Cardinals recalled RHP Dakota Hudson from Memphis Redbirds. |
| 09/19/22 | St. Louis Cardinals optioned 3B Nolan Gorman to Memphis Redbirds. |
| 09/19/22 | St. Louis Cardinals recalled 1B Juan Yepez from Memphis Redbirds. |
| 09/18/22 | St. Louis Cardinals optioned RHP Dakota Hudson to Memphis Redbirds. |
| 09/17/22 | St. Louis Cardinals placed RHP Jordan Hicks on the 15-day injured list retroactive to September 15, 2022. Right arm fatigue and neck spasms. |
| 09/17/22 | St. Louis Cardinals activated LHP Steven Matz from the 15-day injured list. |
| 09/17/22 | St. Louis Cardinals placed LF Tyler O'Neill on the 10-day injured list. Left hamstring strain. |
| 09/17/22 | St. Louis Cardinals activated LHP Steven Matz from the 15-day injured list. |
| 09/17/22 | St. Louis Cardinals activated CF Dylan Carlson from the 10-day injured list. |
| 09/17/22 | St. Louis Cardinals recalled RHP Dakota Hudson from Memphis Redbirds. |
| 09/16/22 | St. Louis Cardinals sent CF Dylan Carlson on a rehab assignment to Memphis Redbirds. |
| 09/13/22 | St. Louis Cardinals sent LHP Steven Matz on a rehab assignment to Memphis Redbirds. |
| 09/10/22 | St. Louis Cardinals optioned RHP James Naile to Memphis Redbirds. |
| 09/10/22 | St. Louis Cardinals recalled LHP Packy Naughton from Memphis Redbirds. |
| 09/09/22 | Oakland Athletics claimed CF Conner Capel off waivers from St. Louis Cardinals. |
| 09/07/22 | St. Louis Cardinals placed CF Dylan Carlson on the 10-day injured list. Left thumb sprain. |
| 09/07/22 | St. Louis Cardinals designated CF Conner Capel for assignment. |
| 09/07/22 | Pittsburgh Pirates claimed RHP Junior Fernandez off waivers from St. Louis Cardinals. |
| 09/07/22 | St. Louis Cardinals recalled OF Alec Burleson from Memphis Redbirds. |
| 09/06/22 | St. Louis Cardinals sent LHP Steven Matz on a rehab assignment to Springfield Cardinals. |
| 09/06/22 | St. Louis Cardinals sent LHP Steven Matz on a rehab assignment to Springfield Cardinals. |
| 09/05/22 | St. Louis Cardinals activated RHP Jack Flaherty from the 60-day injured list. |
| 09/05/22 | St. Louis Cardinals designated RHP Junior Fernandez for assignment. |
| 09/05/22 | St. Louis Cardinals optioned RHP Dakota Hudson to Memphis Redbirds. |
| 09/01/22 | St. Louis Cardinals signed free agent SS Yoerny Junco to a minor league contract. |
| 09/01/22 | St. Louis Cardinals activated CF Ben DeLuzio. |
| 09/01/22 | St. Louis Cardinals recalled RHP James Naile from Memphis Redbirds. |
| 09/01/22 | St. Louis Cardinals selected the contract of CF Ben DeLuzio from Memphis Redbirds. |