Giants Roster & Staff
Transactions
| Date | Transaction |
| 07/31/22 | San Francisco Giants placed 2B Thairo Estrada on the 7-day injured list. Concussion. |
| 07/31/22 | San Francisco Giants designated RHP Tobias Myers for assignment. |
| 07/31/22 | Chicago Cubs traded 2B Dixon Machado to San Francisco Giants for RHP Raynel Espinal. |
| 07/31/22 | Chicago Cubs traded 2B Dixon Machado to San Francisco Giants for RHP Raynel Espinal. |
| 07/29/22 | San Francisco Giants sent RHP Zack Littell on a rehab assignment to San Jose Giants. |
| 07/29/22 | San Francisco Giants placed CF Joc Pederson on the 7-day injured list. Concussion. |
| 07/29/22 | San Francisco Giants recalled 3B Jason Vosler from Sacramento River Cats. |
| 07/28/22 | San Francisco Giants signed C Nomar Diaz. |
| 07/28/22 | C Thomas Gavello roster status changed by San Francisco Giants. |
| 07/28/22 | San Francisco Giants signed LHP John Bertrand. |
| 07/28/22 | San Francisco Giants signed free agent OF Matt Higgins to a minor league contract. |
| 07/28/22 | San Francisco Giants signed free agent LHP Hayden Wynja to a minor league contract. |
| 07/28/22 | San Francisco Giants signed RHP William Kempner. |
| 07/28/22 | San Francisco Giants signed OF Wade Meckler. |
| 07/28/22 | San Francisco Giants signed RHP Hayden Birdsong. |
| 07/28/22 | San Francisco Giants signed 2B Andrew Kachel. |
| 07/28/22 | San Francisco Giants signed SS Justin Bench. |
| 07/28/22 | San Francisco Giants signed free agent OF Carter Howell to a minor league contract. |
| 07/28/22 | San Francisco Giants signed OF Tanner O'Tremba. |
| 07/28/22 | San Francisco Giants signed free agent RHP Davis Hare to a minor league contract. |
| 07/28/22 | San Francisco Giants signed RHP Spencer Miles. |
| 07/28/22 | San Francisco Giants signed RHP Sam Bower. |
| 07/28/22 | San Francisco Giants signed C Thomas Gavello. |
| 07/28/22 | San Francisco Giants signed RHP Tyler Vogel. |
| 07/28/22 | San Francisco Giants signed TWP Reggie Crawford. |
| 07/28/22 | San Francisco Giants signed RHP Liam Simon. |
| 07/28/22 | San Francisco Giants signed LHP Carson Whisenhunt. |
| 07/28/22 | San Francisco Giants signed LHP Jack Choate. |
| 07/28/22 | San Francisco Giants signed C Zach Morgan. |
| 07/27/22 | San Francisco Giants signed LHP John Bertrand. |
| 07/27/22 | San Francisco Giants sent C Curt Casali on a rehab assignment to Sacramento River Cats. |
| 07/26/22 | San Francisco Giants activated 2B Tommy La Stella from the 10-day injured list. |
| 07/26/22 | San Francisco Giants designated RHP Angel Rondon for assignment. |
| 07/26/22 | San Francisco Giants optioned RHP Gregory Santos to Sacramento River Cats. |
| 07/26/22 | Tampa Bay Rays traded LHP Ben Bowden to San Francisco Giants. |
| 07/24/22 | San Francisco Giants placed 3B Evan Longoria on the 10-day injured list. Right hamstring strain. |
| 07/24/22 | San Francisco Giants recalled RHP Gregory Santos from Sacramento River Cats. |
| 07/22/22 | San Francisco Giants sent 2B Tommy La Stella on a rehab assignment to Sacramento River Cats. |
| 07/22/22 | San Francisco Giants signed free agent C Andrew Knapp to a minor league contract. |
| 07/22/22 | San Francisco Giants sent 2B Tommy La Stella on a rehab assignment to Sacramento River Cats. |
| 07/21/22 | San Francisco Giants transferred RHP Mauricio Llovera from the 15-day injured list to the 60-day injured list. |
| 07/21/22 | San Francisco Giants signed free agent RHP Trevor Rosenthal. |
| 07/21/22 | San Francisco Giants placed RHP Trevor Rosenthal on the 15-day injured list. Left hamstring strain. |
| 07/18/22 | Cleveland Guardians traded LHP Alex Young to San Francisco Giants. |
| 07/18/22 | San Francisco Giants sent LHP Aaron Fletcher outright to Sacramento River Cats. |
| 07/16/22 | San Francisco Giants placed RHP Mauricio Llovera on the 10-day injured list. |
| 07/16/22 | San Francisco Giants activated RHP Jakob Junis. |
| 07/16/22 | San Francisco Giants activated 3B Evan Longoria. |
| 07/16/22 | San Francisco Giants placed SS Brandon Crawford on the 10-day injured list. |
| 07/14/22 | San Francisco Giants sent 3B Evan Longoria on a rehab assignment to Sacramento River Cats. |
| 07/14/22 | San Francisco Giants transferred LHP Jose Alvarez from the 15-day injured list to the 60-day injured list. Left elbow inflammation. |
| 07/14/22 | San Francisco Giants released LHP Jake McGee. |
| 07/14/22 | San Francisco Giants claimed LHP Aaron Fletcher off waivers from Pittsburgh Pirates. |
| 07/13/22 | San Francisco Giants signed free agent RHP Kyle Tyler to a minor league contract. |
| 07/13/22 | San Francisco Giants optioned RHP Angel Rondon to Sacramento River Cats. |
| 07/13/22 | San Francisco Giants claimed RHP Angel Rondon off waivers from St. Louis Cardinals. |
| 07/09/22 | San Francisco Giants signed free agent RHP Ronnie Williams to a minor league contract. |
| 07/09/22 | San Francisco Giants designated LHP Jake McGee for assignment. |
| 07/09/22 | San Francisco Giants placed RHP Zack Littell on the 15-day injured list. Left oblique strain. |
| 07/09/22 | San Francisco Giants activated OF Luis Gonzalez. |
| 07/09/22 | San Francisco Giants recalled RHP Yunior Marte from Sacramento River Cats. |
| 07/08/22 | San Francisco Giants placed 3B Colton Welker on the 60-day injured list. Left shoulder surgery. |
| 07/08/22 | San Francisco Giants placed 3B Colton Welker on the 60-day injured list. |
| 07/08/22 | San Francisco Giants activated 2B Thairo Estrada from the 10-day injured list. |
| 07/08/22 | San Francisco Giants placed 2B Tommy La Stella on the 10-day injured list. |
| 07/07/22 | San Francisco Giants sent RHP Jakob Junis on a rehab assignment to ACL Giants Black. |
| 07/07/22 | San Francisco Giants transferred RHP Anthony DeSclafani from the 15-day injured list to the 60-day injured list. Right ankle inflammation. |
| 07/07/22 | Cleveland Guardians traded RHP Tobias Myers to San Francisco Giants. |
| 07/07/22 | San Francisco Giants recalled RHP Zack Littell from Sacramento River Cats. |
| 07/06/22 | San Francisco Giants placed 3B Evan Longoria on the 10-day injured list. Left oblique strain. |
| 07/06/22 | San Francisco Giants sent OF Luis Gonzalez on a rehab assignment to Sacramento River Cats. |
| 07/06/22 | San Francisco Giants recalled C Joey Bart from Sacramento River Cats. |
| 07/05/22 | San Francisco Giants placed LHP Jose Alvarez on the 15-day injured list. Left elbow inflammation. |
| 07/05/22 | San Francisco Giants placed C Curt Casali on the 10-day injured list. Right oblique strain. |
| 07/05/22 | San Francisco Giants activated SS Brandon Crawford from the 10-day injured list. |
| 07/05/22 | San Francisco Giants activated LHP Jose Alvarez. |
| 07/05/22 | San Francisco Giants optioned 2B Donovan Walton to Sacramento River Cats. |
| 07/04/22 | San Francisco Giants optioned RHP Yunior Marte to Sacramento River Cats. |
| 07/04/22 | San Francisco Giants selected the contract of 3B David Villar from Sacramento River Cats. |
| 07/04/22 | San Francisco Giants optioned RHP Sean Hjelle to Sacramento River Cats. |
| 07/04/22 | San Francisco Giants recalled RHP Mauricio Llovera from Sacramento River Cats. |
| 07/03/22 | San Francisco Giants placed 2B Thairo Estrada on the 10-day injured list. |
| 07/03/22 | San Francisco Giants signed free agent RHP Alix Hernandez to a minor league contract. |
| 07/03/22 | San Francisco Giants recalled C Yermin Mercedes from Sacramento River Cats. |
| 07/03/22 | San Francisco Giants optioned 3B Jason Vosler to Sacramento River Cats. |
| 07/03/22 | San Francisco Giants recalled RHP Sean Hjelle from Sacramento River Cats. |
| 07/01/22 | San Francisco Giants placed RHP Anthony DeSclafani on the 15-day injured list retroactive to June 28, 2022. Right ankle inflammation. |
| 07/01/22 | San Francisco Giants recalled 3B Jason Vosler from Sacramento River Cats. |