Giants Roster & Staff
Transactions
| Date | Transaction |
| 09/30/22 | San Francisco Giants signed free agent IF Jean Carlos Sio to a minor league contract. |
| 09/28/22 | San Francisco Giants placed LHP Jarlin Garcia on the paternity list. |
| 09/28/22 | San Francisco Giants recalled RHP Sean Hjelle from Sacramento River Cats. |
| 09/24/22 | San Francisco Giants recalled SS Ford Proctor from Sacramento River Cats. |
| 09/24/22 | San Francisco Giants sent CF Lewis Brinson outright to Sacramento River Cats. |
| 09/22/22 | San Francisco Giants activated RHP Shelby Miller. |
| 09/22/22 | San Francisco Giants optioned RHP Cole Waites to Sacramento River Cats. |
| 09/22/22 | San Francisco Giants selected the contract of RHP Shelby Miller from Sacramento River Cats. |
| 09/21/22 | San Francisco Giants designated CF Lewis Brinson for assignment. |
| 09/21/22 | San Francisco Giants activated RHP Jharel Cotton. |
| 09/21/22 | San Francisco Giants activated RHP Jharel Cotton. |
| 09/21/22 | San Francisco Giants optioned RHP Sean Hjelle to Sacramento River Cats. |
| 09/21/22 | San Francisco Giants recalled 3B Jason Vosler from Sacramento River Cats. |
| 09/19/22 | San Francisco Giants activated LF Austin Slater from the 10-day injured list. |
| 09/19/22 | San Francisco Giants sent LF Willie Calhoun outright to Sacramento River Cats. |
| 09/19/22 | San Francisco Giants optioned OF Heliot Ramos to Sacramento River Cats. |
| 09/18/22 | San Francisco Giants designated LF Willie Calhoun for assignment. |
| 09/18/22 | San Francisco Giants sent 3B Jose Rojas outright to Sacramento River Cats. |
| 09/18/22 | San Francisco Giants claimed RHP Jharel Cotton off waivers from Minnesota Twins. |
| 09/17/22 | San Francisco Giants recalled RHP Sean Hjelle from Sacramento River Cats. |
| 09/17/22 | San Francisco Giants optioned LF Willie Calhoun to Sacramento River Cats. |
| 09/17/22 | San Francisco Giants recalled OF Heliot Ramos from Sacramento River Cats. |
| 09/17/22 | San Francisco Giants optioned RHP Luis Ortiz to Sacramento River Cats. |
| 09/16/22 | San Francisco Giants designated 3B Jose Rojas for assignment. |
| 09/16/22 | San Francisco Giants claimed 1B Taylor Jones off waivers from Houston Astros. |
| 09/16/22 | San Francisco Giants optioned 1B Taylor Jones to Sacramento River Cats. |
| 09/15/22 | San Francisco Giants sent C Patrick Mazeika outright to Sacramento River Cats. |
| 09/13/22 | San Francisco Giants recalled LHP Thomas Szapucki from Sacramento River Cats. |
| 09/13/22 | San Francisco Giants optioned RHP Zack Littell to Sacramento River Cats. |
| 09/12/22 | San Francisco Giants designated C Patrick Mazeika for assignment. |
| 09/12/22 | San Francisco Giants placed 2B Tommy La Stella on the 10-day injured list retroactive to September 11, 2022. Neck spasms. |
| 09/12/22 | San Francisco Giants selected the contract of RHP Cole Waites from Sacramento River Cats. |
| 09/12/22 | San Francisco Giants selected the contract of LF Willie Calhoun from Sacramento River Cats. |
| 09/12/22 | San Francisco Giants optioned LF Austin Dean to Sacramento River Cats. |
| 09/10/22 | San Francisco Giants released RHP Dominic Leone. |
| 09/09/22 | San Francisco Giants placed RHP Dominic Leone on the 15-day injured list. Right elbow inflammation. |
| 09/09/22 | RHP Sean Hjelle returned to Sacramento River Cats from San Francisco Giants. |
| 09/09/22 | San Francisco Giants selected the contract of LF Austin Dean from Sacramento River Cats. |
| 09/08/22 | San Francisco Giants recalled RHP Sean Hjelle from Sacramento River Cats. |
| 09/08/22 | San Francisco Giants sent C Yermin Mercedes outright to Sacramento River Cats. |
| 09/08/22 | San Francisco Giants sent C Andrew Knapp outright to Sacramento River Cats. |
| 09/07/22 | San Francisco Giants optioned OF Bryce Johnson to Sacramento River Cats. |
| 09/07/22 | San Francisco Giants selected the contract of RHP Luis Ortiz, and from Sacramento River Cats. |
| 09/06/22 | San Francisco Giants designated C Andrew Knapp for assignment. |
| 09/06/22 | San Francisco Giants activated C Joey Bart from the 7-day injured list. |
| 09/05/22 | San Francisco Giants placed LF Austin Slater on the 10-day injured list retroactive to September 4, 2022. Left hand sprain. |
| 09/05/22 | San Francisco Giants recalled RHP Yunior Marte from Sacramento River Cats. |
| 09/04/22 | San Francisco Giants transferred 1B Brandon Belt from the 10-day injured list to the 60-day injured list. Right knee inflammation. |
| 09/04/22 | San Francisco Giants claimed 3B Jose Rojas off waivers from Los Angeles Angels. |
| 09/04/22 | San Francisco Giants optioned 3B Jose Rojas to Sacramento River Cats. |
| 09/03/22 | San Francisco Giants placed LHP Alex Wood on the 15-day injured list retroactive to September 1, 2022. Left shoulder impingement. |
| 09/03/22 | San Francisco Giants recalled OF Bryce Johnson from Sacramento River Cats. |
| 09/01/22 | San Francisco Giants activated CF Lewis Brinson. |
| 09/01/22 | San Francisco Giants sent LHP Jonathan Bermudez outright to Sacramento River Cats. |
| 09/01/22 | San Francisco Giants recalled 3B David Villar from Sacramento River Cats. |
| 09/01/22 | San Francisco Giants selected the contract of CF Lewis Brinson from Sacramento River Cats. |
| 09/01/22 | San Francisco Giants sent LHP Andrew Vasquez outright to Sacramento River Cats. |