Cardinals Roster & Staff
Transactions
| Date | Transaction |
| 07/30/22 | St. Louis Cardinals signed OF Chris Rotondo. |
| 07/30/22 | St. Louis Cardinals signed OF Alex Iadisernia. |
| 07/30/22 | St. Louis Cardinals activated RHP Dakota Hudson from the 15-day injured list. |
| 07/30/22 | St. Louis Cardinals optioned RHP James Naile to Memphis Redbirds. |
| 07/30/22 | St. Louis Cardinals recalled SS Paul DeJong from Memphis Redbirds. |
| 07/30/22 | St. Louis Cardinals traded 2B Edmundo Sosa to Philadelphia Phillies for LHP JoJo Romero. |
| 07/30/22 | St. Louis Cardinals traded 2B Edmundo Sosa to Philadelphia Phillies for LHP JoJo Romero. |
| 07/29/22 | St. Louis Cardinals signed C Jimmy Crooks III. |
| 07/29/22 | St. Louis Cardinals signed SS Michael Curialle. |
| 07/29/22 | OF Victor Scott II roster status changed by St. Louis Cardinals. |
| 07/29/22 | St. Louis Cardinals signed OF Victor Scott II. |
| 07/29/22 | St. Louis Cardinals signed SS Brody Moore. |
| 07/28/22 | St. Louis Cardinals activated 1B Paul Goldschmidt from the restricted list. |
| 07/28/22 | St. Louis Cardinals activated C Austin Romine from the restricted list. |
| 07/28/22 | St. Louis Cardinals activated 3B Nolan Arenado from the restricted list. |
| 07/28/22 | St. Louis Cardinals sent C Yadier Molina on a rehab assignment to Memphis Redbirds. |
| 07/28/22 | St. Louis Cardinals optioned CF Conner Capel to Memphis Redbirds. |
| 07/28/22 | 2B Cory Spangenberg returned to Memphis Redbirds from St. Louis Cardinals. |
| 07/28/22 | St. Louis Cardinals optioned C Ivan Herrera to Memphis Redbirds. |
| 07/27/22 | St. Louis Cardinals signed LHP John Lynch. |
| 07/27/22 | St. Louis Cardinals recalled CF Conner Capel and from Memphis Redbirds. |
| 07/25/22 | St. Louis Cardinals placed C Austin Romine on the restricted list. |
| 07/25/22 | St. Louis Cardinals placed 1B Paul Goldschmidt on the restricted list. |
| 07/25/22 | St. Louis Cardinals placed 3B Nolan Arenado on the restricted list. |
| 07/25/22 | St. Louis Cardinals signed RHP Joseph King. |
| 07/25/22 | St. Louis Cardinals selected the contract of 2B Cory Spangenberg from Memphis Redbirds. |
| 07/25/22 | St. Louis Cardinals recalled C Ivan Herrera from Memphis Redbirds. |
| 07/24/22 | St. Louis Cardinals sent RHP Dakota Hudson on a rehab assignment to Memphis Redbirds. |
| 07/24/22 | St. Louis Cardinals signed free agent RHP Cade Winquest to a minor league contract. |
| 07/24/22 | St. Louis Cardinals recalled RHP James Naile from Memphis Redbirds. |
| 07/23/22 | St. Louis Cardinals signed RHP Max Rajcic. |
| 07/23/22 | St. Louis Cardinals signed LHP Pete Hansen. |
| 07/22/22 | St. Louis Cardinals sent CF Harrison Bader on a rehab assignment to Memphis Redbirds. |
| 07/22/22 | St. Louis Cardinals signed LHP Cooper Hjerpe. |
| 07/22/22 | St. Louis Cardinals sent CF Harrison Bader on a rehab assignment to Memphis Redbirds. |
| 07/22/22 | St. Louis Cardinals signed free agent SS Errol Robinson to a minor league contract. |
| 07/22/22 | St. Louis Cardinals signed LHP Brycen Mautz. |
| 07/21/22 | St. Louis Cardinals signed RHP Tanner Jacobson. |
| 07/21/22 | RHP Tanner Jacobson roster status changed by St. Louis Cardinals. |
| 07/19/22 | St. Louis Cardinals signed RHP Hunter Hayes. |
| 07/19/22 | St. Louis Cardinals signed RHP D.J. Carpenter. |
| 07/19/22 | St. Louis Cardinals signed RHP Chandler Arnold. |
| 07/17/22 | St. Louis Cardinals placed RHP Drew VerHagen on the 15-day injured list retroactive to July 15, 2022. Right hip impingement. |
| 07/17/22 | St. Louis Cardinals activated LHP Steven Matz. |
| 07/15/22 | St. Louis Cardinals placed 1B Juan Yepez on the 10-day injured list. Right forearm strain. |
| 07/15/22 | St. Louis Cardinals placed RHP Dakota Hudson on the 15-day injured list. Neck strain. |
| 07/15/22 | St. Louis Cardinals recalled LF Lars Nootbaar and from Memphis Redbirds. |
| 07/15/22 | St. Louis Cardinals recalled LHP Zack Thompson from Memphis Redbirds. |
| 07/14/22 | St. Louis Cardinals activated LF Tyler O'Neill. |
| 07/14/22 | St. Louis Cardinals optioned LF Lars Nootbaar to Memphis Redbirds. |
| 07/13/22 | St. Louis Cardinals activated RHP Drew VerHagen. |
| 07/13/22 | St. Louis Cardinals optioned LHP Matthew Liberatore to Memphis Redbirds. |
| 07/13/22 | San Francisco Giants claimed RHP Angel Rondon off waivers from St. Louis Cardinals. |
| 07/11/22 | St. Louis Cardinals activated LHP T.J. McFarland. |
| 07/11/22 | St. Louis Cardinals transferred RHP Jack Flaherty from the 15-day injured list to the 60-day injured list. Right shoulder strain. |
| 07/11/22 | St. Louis Cardinals optioned LHP Zack Thompson to Memphis Redbirds. |
| 07/09/22 | St. Louis Cardinals activated LF Corey Dickerson. |
| 07/09/22 | St. Louis Cardinals released RHP Nick Wittgren. |
| 07/09/22 | St. Louis Cardinals optioned CF Conner Capel to Memphis Redbirds. |
| 07/08/22 | St. Louis Cardinals activated LHP Genesis Cabrera from the 10-day injured list. |
| 07/08/22 | St. Louis Cardinals designated RHP Angel Rondon for assignment. |
| 07/08/22 | St. Louis Cardinals optioned RHP James Naile to Memphis Redbirds. |
| 07/06/22 | St. Louis Cardinals sent RHP Drew VerHagen on a rehab assignment to Peoria Chiefs. |
| 07/06/22 | St. Louis Cardinals sent LHP T.J. McFarland on a rehab assignment to Memphis Redbirds. |
| 07/06/22 | St. Louis Cardinals sent LF Corey Dickerson on a rehab assignment to Memphis Redbirds. |
| 07/04/22 | St. Louis Cardinals sent LF Tyler O'Neill on a rehab assignment to Memphis Redbirds. |
| 07/04/22 | St. Louis Cardinals selected the contract of C Austin Romine from Memphis Redbirds. |
| 07/04/22 | St. Louis Cardinals optioned C Ivan Herrera to Memphis Redbirds. |
| 07/02/22 | St. Louis Cardinals activated RHP Jordan Hicks. |
| 07/02/22 | St. Louis Cardinals designated RHP Nick Wittgren for assignment. |
| 07/02/22 | St. Louis Cardinals recalled LHP Matthew Liberatore from Memphis Redbirds. |
| 07/02/22 | St. Louis Cardinals optioned RHP Jake Woodford to Memphis Redbirds. |