Mariners Roster & Staff
Mariners
| Date | Transaction |
| 05/26/22 | Seattle Mariners optioned RHP Drew Steckenrider to Tacoma Rainiers. |
| 05/24/22 | Seattle Mariners activated CF Kyle Lewis. |
| 05/24/22 | Seattle Mariners signed free agent RHP Michael Flynn to a minor league contract. |
| 05/24/22 | Seattle Mariners sent RHP Adrian Sampson outright to Tacoma Rainiers. |
| 05/24/22 | Seattle Mariners optioned LHP Danny Young to Tacoma Rainiers. |
| 05/23/22 | Seattle Mariners released RF Steven Souza Jr.. |
| 05/22/22 | Seattle Mariners designated RF Steven Souza Jr. for assignment. |
| 05/22/22 | Seattle Mariners selected the contract of 2B Sam Haggerty from Tacoma Rainiers. |
| 05/22/22 | Seattle Mariners optioned LF Justin Upton to Tacoma Rainiers. |
| 05/22/22 | Seattle Mariners recalled LF Taylor Trammell from Tacoma Rainiers. |
| 05/21/22 | Seattle Mariners signed free agent C Andrew Knapp to a minor league contract. |
| 05/21/22 | Seattle Mariners designated RHP Adrian Sampson for assignment. |
| 05/21/22 | Seattle Mariners signed free agent LF Justin Upton. |
| 05/20/22 | Seattle Mariners activated RHP Matthew Festa from the 15-day injured list. |
| 05/20/22 | Seattle Mariners optioned RHP Wyatt Mills to Tacoma Rainiers. |
| 05/19/22 | Seattle Mariners activated RHP Drew Steckenrider from the restricted list. |
| 05/19/22 | LHP Roenis Elias returned to Tacoma Rainiers from Seattle Mariners. |
| 05/18/22 | Seattle Mariners sent 1B Evan White on a rehab assignment to Tacoma Rainiers. |
| 05/16/22 | Seattle Mariners placed RHP Drew Steckenrider on the restricted list. |
| 05/16/22 | Seattle Mariners selected the contract of LHP Roenis Elias from Tacoma Rainiers. |
| 05/16/22 | Seattle Mariners traded RHP Yohan Ramirez to Cleveland Guardians. |
| 05/14/22 | Seattle Mariners placed RHP Erik Swanson on the 15-day injured list. Right elbow inflammation. |
| 05/14/22 | Seattle Mariners traded OF Stuart Fairchild to San Francisco Giants for 2B Alex Blandino and cash. |
| 05/14/22 | Seattle Mariners traded OF Stuart Fairchild to San Francisco Giants for 2B Alex Blandino and cash. |
| 05/14/22 | Seattle Mariners recalled LHP Danny Young from Tacoma Rainiers. |
| 05/13/22 | Seattle Mariners designated RHP Yohan Ramirez for assignment. |
| 05/13/22 | Seattle Mariners activated RHP Sergio Romo. |
| 05/13/22 | Seattle Mariners activated 1B Mike Ford. |
| 05/13/22 | Seattle Mariners signed free agent C Luke Roskam to a minor league contract. |
| 05/13/22 | Seattle Mariners designated OF Stuart Fairchild for assignment. |
| 05/13/22 | Seattle Mariners signed free agent C Andrew Miller to a minor league contract. |
| 05/13/22 | Seattle Mariners claimed RHP Adrian Sampson off waivers from Chicago Cubs. |
| 05/13/22 | Seattle Mariners optioned OF Stuart Fairchild to Tacoma Rainiers. |
| 05/13/22 | Seattle Mariners optioned OF Jarred Kelenic to Tacoma Rainiers. |
| 05/13/22 | Seattle Mariners optioned LHP Danny Young to Tacoma Rainiers. |
| 05/13/22 | Seattle Mariners selected the contract of RF Steven Souza Jr. from Tacoma Rainiers. |
| 05/13/22 | Seattle Mariners optioned RHP Adrian Sampson to Tacoma Rainiers. |
| 05/12/22 | San Francisco Giants traded 1B Mike Ford to Seattle Mariners for cash. |
| 05/11/22 | Seattle Mariners signed free agent RHP Matt Mogollon to a minor league contract. |
| 05/11/22 | Seattle Mariners signed free agent LHP Bryan Warzek to a minor league contract. |
| 05/11/22 | San Francisco Giants traded RHP Prelander Berroa to Seattle Mariners for 2B Donovan Walton. |
| 05/11/22 | San Francisco Giants traded RHP Prelander Berroa to Seattle Mariners for 2B Donovan Walton. |
| 05/10/22 | Seattle Mariners sent RHP Sergio Romo on a rehab assignment to Tacoma Rainiers. |
| 05/09/22 | Seattle Mariners sent LHP Nick Margevicius outright to Tacoma Rainiers. |
| 05/08/22 | Seattle Mariners transferred RHP Ken Giles from the 10-day injured list to the 60-day injured list. Right middle finger sprain. |
| 05/08/22 | Seattle Mariners selected the contract of RHP George Kirby from Arkansas Travelers. |
| 05/08/22 | Seattle Mariners optioned RHP Riley O'Brien to Tacoma Rainiers. |
| 05/07/22 | Seattle Mariners placed C Tom Murphy on the 10-day injured list. Dislocated left shoulder. |
| 05/07/22 | Seattle Mariners recalled C Cal Raleigh from Tacoma Rainiers. |
| 05/05/22 | Seattle Mariners designated LHP Nick Margevicius for assignment. |
| 05/05/22 | Seattle Mariners placed RHP Matthew Festa on the 15-day injured list retroactive to May 4, 2022. Right elbow tendinitis. |
| 05/05/22 | Seattle Mariners optioned RHP Matt Brash to Tacoma Rainiers. |
| 05/05/22 | Seattle Mariners selected the contract of LHP Danny Young from Tacoma Rainiers. |
| 05/05/22 | Seattle Mariners recalled RHP Riley O'Brien from Tacoma Rainiers. |
| 05/05/22 | Seattle Mariners sent RHP Matt Koch outright to Tacoma Rainiers. |
| 05/03/22 | Seattle Mariners signed free agent LHP Fernando Abad to a minor league contract. |
| 05/03/22 | Seattle Mariners sent CF Kyle Lewis on a rehab assignment to Tacoma Rainiers. |
| 05/02/22 | Seattle Mariners optioned 2B Donovan Walton to Tacoma Rainiers. |
| 05/02/22 | Seattle Mariners optioned LHP Justus Sheffield to Tacoma Rainiers. |