Orioles Roster & Staff
Transactions
| Date | Transaction |
| 07/31/21 | Baltimore Orioles sent LHP Bruce Zimmermann on a rehab assignment to Aberdeen IronBirds. |
| 07/30/21 | Baltimore Orioles traded SS Freddy Galvis to Philadelphia Phillies for RHP Tyler Burch. |
| 07/30/21 | Baltimore Orioles traded SS Freddy Galvis to Philadelphia Phillies for RHP Tyler Burch. |
| 07/30/21 | Baltimore Orioles claimed LHP Ryan Hartman off waivers from Houston Astros. |
| 07/30/21 | Baltimore Orioles activated RF Anthony Santander from the 10-day injured list. |
| 07/30/21 | Baltimore Orioles reassigned LHP Ryan Hartman to the minor leagues. |
| 07/30/21 | Baltimore Orioles optioned RHP Thomas Eshelman to Norfolk Tides. |
| 07/30/21 | Baltimore Orioles traded RHP Shawn Armstrong to Tampa Bay Rays for cash. |
| 07/30/21 | Baltimore Orioles optioned LHP Ryan Hartman to Norfolk Tides. |
| 07/29/21 | Baltimore Orioles sent SS Richie Martin on a rehab assignment to Bowie Baysox. |
| 07/27/21 | Baltimore Orioles sent SS Richie Martin on a rehab assignment to FCL Orioles Orange. |
| 07/27/21 | Baltimore Orioles signed RHP Daniel Lloyd. |
| 07/27/21 | Baltimore Orioles signed free agent RHP Duany Gomez to a minor league contract. |
| 07/26/21 | Baltimore Orioles sent LHP Bruce Zimmermann on a rehab assignment to FCL Orioles Black. |
| 07/24/21 | Baltimore Orioles signed C Connor Pavolony. |
| 07/24/21 | Baltimore Orioles signed SS Collin Burns. |
| 07/24/21 | Baltimore Orioles selected the contract of RHP Conner Greene from Norfolk Tides. |
| 07/23/21 | Baltimore Orioles signed 3B Ryan Higgins. |
| 07/23/21 | Baltimore Orioles signed RHP Ryan Long. |
| 07/23/21 | Baltimore Orioles signed RHP Peter Van Loon. |
| 07/23/21 | Baltimore Orioles activated 3B Maikel Franco. |
| 07/23/21 | Baltimore Orioles signed RHP Justin Armbruester. |
| 07/23/21 | Baltimore Orioles signed C Creed Willems. |
| 07/23/21 | Baltimore Orioles signed RHP Keagan Gillies. |
| 07/23/21 | RHP Ryan Long roster status changed by Baltimore Orioles. |
| 07/23/21 | Baltimore Orioles placed RHP Tyler Wells on the 10-day injured list. Right wrist tendinitis. |
| 07/23/21 | Baltimore Orioles signed RHP Alex Pham. |
| 07/23/21 | Baltimore Orioles signed OF Billy Cook. |
| 07/23/21 | Baltimore Orioles signed 1B Jacob Teter. |
| 07/23/21 | Baltimore Orioles signed RHP Conor Grady. |
| 07/23/21 | Baltimore Orioles signed OF Reed Trimble. |
| 07/23/21 | Baltimore Orioles signed RHP Carlos Tavera. |
| 07/22/21 | Baltimore Orioles signed RHP Dylan Heid. |
| 07/22/21 | Baltimore Orioles optioned 3B Kelvin Gutierrez to Norfolk Tides. |
| 07/21/21 | Baltimore Orioles placed LHP Keegan Akin on the 10-day injured list. |
| 07/21/21 | Baltimore Orioles recalled LHP Alexander Wells from Norfolk Tides. |
| 07/21/21 | Baltimore Orioles placed RF Anthony Santander on the 10-day injured list. |
| 07/21/21 | Baltimore Orioles recalled CF Ryan McKenna from Norfolk Tides. |
| 07/20/21 | Baltimore Orioles optioned CF Ryan McKenna to Norfolk Tides. |
| 07/20/21 | Baltimore Orioles signed free agent RHP Eduardo Torres to a minor league contract. |
| 07/20/21 | Baltimore Orioles sent 3B Maikel Franco on a rehab assignment to FCL Orioles Orange. |
| 07/20/21 | Baltimore Orioles activated LHP John Means. |
| 07/17/21 | Baltimore Orioles signed OF Colton Cowser. |
| 07/17/21 | Baltimore Orioles activated RHP Jorge Lopez from the bereavement list. |
| 07/16/21 | Baltimore Orioles signed 2B Connor Norby. |
| 07/15/21 | Baltimore Orioles signed free agent RHP Preston Price to a minor league contract. |
| 07/15/21 | Baltimore Orioles sent LHP John Means on a rehab assignment to Norfolk Tides. |
| 07/14/21 | Baltimore Orioles signed C Logan Michaels. |
| 07/14/21 | Baltimore Orioles signed free agent RHP Daniel Federman to a minor league contract. |
| 07/14/21 | Baltimore Orioles placed RHP Jorge Lopez on the bereavement list. |
| 07/14/21 | Baltimore Orioles signed free agent RHP Carson Carter to a minor league contract. |
| 07/10/21 | Los Angeles Dodgers traded RHP Hugo Beltran to Baltimore Orioles for cash. |
| 07/09/21 | Baltimore Orioles sent LHP John Means on a rehab assignment to Bowie Baysox. |
| 07/08/21 | Baltimore Orioles recalled RHP Shaun Anderson from Norfolk Tides. |
| 07/08/21 | Baltimore Orioles optioned LHP Zac Lowther to Norfolk Tides. |
| 07/07/21 | Baltimore Orioles placed 3B Maikel Franco on the 10-day injured list. Right ankle sprain. |
| 07/07/21 | Baltimore Orioles recalled 3B Kelvin Gutierrez from Norfolk Tides. |
| 07/05/21 | Baltimore Orioles signed free agent RHP Gregori Vasquez to a minor league contract. |
| 07/05/21 | Baltimore Orioles sent RHP Konner Wade outright to Norfolk Tides. |
| 07/04/21 | Baltimore Orioles optioned RHP Isaac Mattson to Norfolk Tides. |
| 07/04/21 | Baltimore Orioles sent LHP John Means on a rehab assignment to Aberdeen IronBirds. |
| 07/04/21 | Baltimore Orioles activated RHP Cesar Valdez from the 10-day injured list. |
| 07/04/21 | Baltimore Orioles sent LHP John Means on a rehab assignment to Aberdeen IronBirds. |
| 07/03/21 | Baltimore Orioles optioned RHP Shaun Anderson to Norfolk Tides. |
| 07/03/21 | Baltimore Orioles designated RHP Konner Wade for assignment. |
| 07/03/21 | Baltimore Orioles placed RHP Travis Lakins Sr. on the 60-day injured list. Right elbow pain. |
| 07/03/21 | Kansas City Royals traded 3B Kelvin Gutierrez to Baltimore Orioles for cash. |
| 07/03/21 | Baltimore Orioles sent 2B Stevie Wilkerson outright to Norfolk Tides. |
| 07/03/21 | Baltimore Orioles optioned 3B Kelvin Gutierrez to Norfolk Tides. |
| 07/03/21 | Baltimore Orioles claimed RHP Shaun Anderson off waivers from Texas Rangers. |
| 07/02/21 | Baltimore Orioles signed free agent RHP Pedro Figueroa to a minor league contract. |
| 07/02/21 | Baltimore Orioles recalled LHP Zac Lowther from Norfolk Tides. |
| 07/02/21 | Baltimore Orioles placed RHP Hunter Harvey on the 10-day injured list. Right lat strain. |