Orioles Roster & Staff
Transactions
| Date | Transaction |
| 06/30/21 | Baltimore Orioles designated 2B Stevie Wilkerson for assignment. |
| 06/30/21 | Baltimore Orioles placed RHP Travis Lakins Sr. on the 10-day injured list. Right elbow pain. |
| 06/30/21 | Baltimore Orioles optioned LHP Alexander Wells to Norfolk Tides. |
| 06/30/21 | Baltimore Orioles selected the contract of RHP Spenser Watkins from Norfolk Tides. |
| 06/30/21 | Baltimore Orioles recalled RHP Isaac Mattson from Norfolk Tides. |
| 06/27/21 | Baltimore Orioles optioned 2B Stevie Wilkerson to Norfolk Tides. |
| 06/27/21 | Baltimore Orioles sent RHP Mickey Jannis outright to Norfolk Tides. |
| 06/27/21 | Baltimore Orioles placed SS Freddy Galvis on the 10-day injured list. Right quadriceps strain. |
| 06/27/21 | Baltimore Orioles recalled 2B Ramon Urias from Norfolk Tides. |
| 06/27/21 | Baltimore Orioles optioned RHP Konner Wade to Norfolk Tides. |
| 06/27/21 | Baltimore Orioles recalled CF Ryan McKenna from Norfolk Tides. |
| 06/27/21 | Baltimore Orioles recalled SS Domingo Leyba from Norfolk Tides. |
| 06/26/21 | RHP Mac Sceroler returned to Cincinnati Reds from Baltimore Orioles. |
| 06/25/21 | Baltimore Orioles selected the contract of RHP Konner Wade from Norfolk Tides. |
| 06/25/21 | Baltimore Orioles optioned RHP Dean Kremer to Norfolk Tides. |
| 06/25/21 | Baltimore Orioles recalled LHP Alexander Wells from Norfolk Tides. |
| 06/25/21 | Baltimore Orioles designated RHP Mickey Jannis for assignment. |
| 06/25/21 | New York Mets claimed C Chance Sisco off waivers from Baltimore Orioles. |
| 06/22/21 | Baltimore Orioles designated RHP Mac Sceroler for assignment. |
| 06/22/21 | Baltimore Orioles selected the contract of RHP Mickey Jannis from Norfolk Tides. |
| 06/21/21 | Baltimore Orioles recalled RHP Travis Lakins Sr. from Norfolk Tides. |
| 06/21/21 | Baltimore Orioles placed RHP Cesar Valdez on the 10-day injured list. Lower back strain. |
| 06/18/21 | Baltimore Orioles selected the contract of RHP Thomas Eshelman from Norfolk Tides. |
| 06/18/21 | Baltimore Orioles placed LHP Bruce Zimmermann on the 10-day injured list. Left bicep tendinitis. |
| 06/18/21 | Baltimore Orioles designated C Chance Sisco for assignment. |
| 06/15/21 | Pittsburgh Pirates traded CF Jose Berroa to Baltimore Orioles for 3B Taylor Davis. |
| 06/15/21 | Pittsburgh Pirates traded CF Jose Berroa to Baltimore Orioles for 3B Taylor Davis. |
| 06/14/21 | Baltimore Orioles optioned RHP Travis Lakins Sr. to Norfolk Tides. |
| 06/14/21 | Baltimore Orioles recalled RHP Dean Kremer from Norfolk Tides. |
| 06/11/21 | Baltimore Orioles sent RHP Shawn Armstrong outright to Norfolk Tides. |
| 06/11/21 | Baltimore Orioles activated RF Austin Hays from the 10-day injured list. |
| 06/10/21 | Baltimore Orioles optioned CF Ryan McKenna to Norfolk Tides. |
| 06/09/21 | Baltimore Orioles signed free agent RHP Logan Gillaspie to a minor league contract. |
| 06/08/21 | Baltimore Orioles optioned 2B Ramon Urias to Norfolk Tides. |
| 06/08/21 | Baltimore Orioles activated SS Pat Valaika from the bereavement list. |
| 06/08/21 | Baltimore Orioles sent RF Austin Hays on a rehab assignment to Norfolk Tides. |
| 06/08/21 | Baltimore Orioles activated RHP Mac Sceroler. |
| 06/07/21 | Baltimore Orioles optioned LHP Zac Lowther to Norfolk Tides. |
| 06/06/21 | St. Louis Cardinals claimed LHP Brandon Waddell off waivers from Baltimore Orioles. |
| 06/06/21 | Baltimore Orioles placed LHP John Means on the 10-day injured list. Left shoulder strain. |
| 06/06/21 | Baltimore Orioles recalled LHP Zac Lowther from Norfolk Tides. |
| 06/04/21 | Baltimore Orioles activated RHP Hunter Harvey. |
| 06/04/21 | Baltimore Orioles optioned SS Domingo Leyba to Norfolk Tides. |
| 06/04/21 | Baltimore Orioles recalled RHP Travis Lakins Sr. from Norfolk Tides. |
| 06/04/21 | Baltimore Orioles designated RHP Shawn Armstrong for assignment. |
| 06/04/21 | Baltimore Orioles recalled 2B Ramon Urias from Norfolk Tides. |
| 06/04/21 | Baltimore Orioles placed SS Pat Valaika on the bereavement list. |
| 06/04/21 | Baltimore Orioles designated LHP Brandon Waddell for assignment. |
| 06/04/21 | Baltimore Orioles claimed SS Domingo Leyba off waivers from Arizona Diamondbacks. |
| 06/03/21 | Baltimore Orioles optioned LHP Zac Lowther to Norfolk Tides. |
| 06/02/21 | Baltimore Orioles recalled LHP Zac Lowther from Norfolk Tides. |
| 06/02/21 | Baltimore Orioles optioned 3B Tyler Nevin to Norfolk Tides. |