Orioles Roster & Staff
Transactions
| Date | Transaction |
| 04/29/22 | Baltimore Orioles recalled RHP Kyle Bradish from Norfolk Tides. |
| 04/29/22 | Baltimore Orioles optioned RHP Mike Baumann to Norfolk Tides. |
| 04/29/22 | Baltimore Orioles recalled 3B Tyler Nevin from Norfolk Tides. |
| 04/26/22 | Baltimore Orioles placed RHP Chris Ellis on the 10-day injured list retroactive to April 25, 2022. Right shoulder inflammation. |
| 04/26/22 | Baltimore Orioles sent LF DJ Stewart outright to Norfolk Tides. |
| 04/26/22 | Baltimore Orioles recalled LHP Alexander Wells from Norfolk Tides. |
| 04/19/22 | Baltimore Orioles designated LF DJ Stewart for assignment. |
| 04/19/22 | Baltimore Orioles selected the contract of RHP Chris Ellis from Norfolk Tides. |
| 04/19/22 | Baltimore Orioles optioned RHP Marcos Diplan to Norfolk Tides. |
| 04/17/22 | Baltimore Orioles optioned LHP Alexander Wells to Norfolk Tides. |
| 04/17/22 | Baltimore Orioles selected the contract of RHP Marcos Diplan from Norfolk Tides. |
| 04/15/22 | Baltimore Orioles placed LHP John Means on the 10-day injured list retroactive to April 14, 2022. Left elbow strain. |
| 04/15/22 | Baltimore Orioles selected the contract of RHP Travis Lakins Sr. from Norfolk Tides. |
| 04/15/22 | Baltimore Orioles sent LHP Kevin Smith outright to Norfolk Tides. |
| 04/14/22 | Baltimore Orioles transferred LHP John Means from the 10-day injured list to the 60-day injured list. Left elbow sprain. |
| 04/14/22 | Baltimore Orioles placed LHP John Means on the 10-day injured list. Left elbow strain. |
| 04/14/22 | Baltimore Orioles placed LHP John Means on the 10-day injured list. Left elbow strain. |
| 04/11/22 | Baltimore Orioles activated RHP Joey Krehbiel. |
| 04/11/22 | Baltimore Orioles activated RHP Spenser Watkins. |
| 04/11/22 | Baltimore Orioles placed RHP Spenser Watkins on the 15-day injured list. Right elbow contusion. |
| 04/11/22 | Baltimore Orioles activated RHP Spenser Watkins. |
| 04/11/22 | Baltimore Orioles placed RHP Dean Kremer on the 10-day injured list retroactive to April 8, 2022. Left oblique strain. |
| 04/11/22 | Baltimore Orioles optioned LF DJ Stewart to Norfolk Tides. |
| 04/11/22 | Baltimore Orioles recalled LHP Alexander Wells, and from Norfolk Tides. |
| 04/11/22 | Baltimore Orioles selected the contract of RHP Spenser Watkins from Norfolk Tides. |
| 04/08/22 | Baltimore Orioles signed free agent RHP Matt Harvey to a minor league contract. |
| 04/08/22 | Baltimore Orioles recalled RHP Isaac Mattson from Norfolk Tides. |
| 04/08/22 | Baltimore Orioles sent RHP Isaac Mattson outright to Norfolk Tides. |
| 04/07/22 | Baltimore Orioles activated SS Jorge Mateo. |
| 04/07/22 | Baltimore Orioles activated SS Jorge Mateo. |
| 04/07/22 | Baltimore Orioles activated RHP Bryan Baker. |
| 04/07/22 | Baltimore Orioles activated CF Ryan McKenna. |
| 04/07/22 | Baltimore Orioles activated SS Jorge Mateo. |
| 04/07/22 | Baltimore Orioles selected the contract of SS Chris Owings, and from Norfolk Tides. |
| 04/07/22 | Baltimore Orioles traded SS Mason McCoy to Seattle Mariners. |
| 04/07/22 | Baltimore Orioles selected the contract of C Anthony Bemboom, and from Norfolk Tides. |
| 04/06/22 | Baltimore Orioles optioned 3B Tyler Nevin to Norfolk Tides. |
| 04/06/22 | Baltimore Orioles optioned RHP Isaac Mattson to Norfolk Tides. |
| 04/05/22 | Baltimore Orioles optioned LHP Zac Lowther to Norfolk Tides. |
| 04/03/22 | C Creed Willems and assigned to Baltimore Orioles. |
| 04/03/22 | LF Cristopher Cespedes and assigned to Baltimore Orioles. |
| 04/03/22 | Baltimore Orioles traded RHP Cole Sulser and LHP Tanner Scott to Miami Marlins for OF Kevin Guerrero and LHP Antonio Velez. |
| 04/03/22 | Baltimore Orioles traded RHP Cole Sulser and LHP Tanner Scott to Miami Marlins for OF Kevin Guerrero and LHP Antonio Velez. |
| 04/03/22 | Baltimore Orioles traded RHP Cole Sulser and LHP Tanner Scott to Miami Marlins for OF Kevin Guerrero and LHP Antonio Velez. |
| 04/03/22 | Baltimore Orioles traded RHP Cole Sulser and LHP Tanner Scott to Miami Marlins for OF Kevin Guerrero and LHP Antonio Velez. |
| 04/02/22 | SS Collin Burns and assigned to Baltimore Orioles. |
| 04/02/22 | C Connor Pavolony and assigned to Baltimore Orioles. |
| 04/02/22 | OF Donta' Williams and assigned to Baltimore Orioles. |
| 04/01/22 | CF Mason Janvrin roster status changed by Baltimore Orioles. |
| 04/01/22 | RHP Houston Roth and assigned to Baltimore Orioles. |
| 04/01/22 | SS Yorkislandy Alvarez and assigned to Baltimore Orioles. |
| 04/01/22 | RHP Tyler Burch and assigned to Baltimore Orioles. |
| 04/01/22 | C Ramon Rodriguez and assigned to Baltimore Orioles. |
| 04/01/22 | CF Mason Janvrin assigned to Baltimore Orioles. |